Charge syndrome and aggressive behavior11/23/2023 ![]() 3 Due to this increased susceptibility, extra care must be taken in the management of juvenile epileptic patients, particularly in the utilization of antiepileptic medications that carry a risk of adverse behavioral side effects. This connection between epilepsy and behavioral disorders has been so widely reported in the medical literature that it has been referred to as the “Bidirectional Hypothesis,” which posits that the two conditions are manifestations of the same underlying functional impairments in common pathways responsible for regulating mood and behavior. reported finding the prevalence of behavioral comorbidities in pediatric patients to be significantly higher in epileptics compared with nonepileptics (39.1% vs. In a case‐control retrospective study examining this relationship, Anita et al 2. 1 Childhood epilepsy is also frequently comorbid with cognitive and developmental delays and the development of both psychiatric and behavioral disorders, including autism spectrum and attention‐deficit hyperactivity disorders. in developed countries and in underdeveloped countries. Our observations suggest that Levetiracetam remains a safe and effective first‐line antiepileptic whose adverse behavioral side effect profile can be properly managed with close patient monitoring and dose titration.Įpilepsy is a common neurological disorder affecting children, with rates of incidence as high as 5. His symptoms resolved rapidly after return of his medication dosing to baseline, with no further sequelae noted. In this report, we present a teenage male patient with a history of seizure disorder who developed sudden, severe behavioral abnormalities and aggression following increases in his Levetiracetam dosing. The development of acute aggression requiring termination of Levetiracetam therapy has been rarely reported in the medical literature but poses a limiting effect on treatment options for refractory epilepsy in pediatric patients. While Levetiracetam is generally well‐tolerated, mild mood‐related side effects (e.g., anxiety, agitation, and depression) have been observed in a minority of patients in the days following initiation of therapy or changes in dosing. ![]() Levetiracetam is a second‐generation antiepileptic medication used to treat a wide range of partial and generalized seizure disorders.
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